Structure-based design of PDK1 inhibitorsPOULSEN, Anders; BLANCHARD, Stéphanie; KAI SOH, Chang et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 305-307, issn 0960-894X, 3 p.Article

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitorsGUSTIN, Darin J; ZHIHUA MA; CARLSON, Timothy J et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 8, pp 2492-2496, issn 0960-894X, 5 p.Article

Structure-Based Design and Synthesis of Novel Dual-Target Inhibitors against Cyanobacterial Fructose-1,6-Bisphosphate Aldolase and Fructose-1,6-BisphosphataseDING LI; XINYA HAN; QIDONG TU et al.Journal of agricultural and food chemistry (Print). 2013, Vol 61, Num 31, pp 7453-7461, issn 0021-8561, 9 p.Article

The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifsWATSON, Nigel S; ADAMS, Carl; HARLING, John D et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 6, pp 1588-1592, issn 0960-894X, 5 p.Article

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2LEDEBOER, Mark W; PIERCE, Albert C; SHLYAKTER, Dina et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 23, pp 6529-6533, issn 0960-894X, 5 p.Article

Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifsKLEANTHOUS, Sawas; BORTHWICK, Alan D; HORTENSE, Eric et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 2, pp 618-622, issn 0960-894X, 5 p.Article

Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitorsSCHEIPER, Bodo; MATTER, Hans; STEINHAGEN, Henning et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 21, pp 6268-6272, issn 0960-894X, 5 p.Article

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3SWAHN, Britt-Marie; YAFENG XUE; ARZEL, Erwan et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 5, pp 1397-1401, issn 0960-894X, 5 p.Article

Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibitionDOSSETTER, Alexander G; BOWYER, Jonathan; KRAPP, Stephan et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 17, pp 5563-5568, issn 0960-894X, 6 p.Article

Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifsYOUNG, Robert J; ADAMS, Carl; FOSTER, Graham et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 6, pp 1582-1587, issn 0960-894X, 6 p.Article

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitorsYIBIN XIANG; HIRTH, Bradford; JINYU LIU et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 10, pp 3050-3056, issn 0960-894X, 7 p.Article

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidateANSELM, Lillli; BANNER, David W; PANDAY, Narendra et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 17, pp 5313-5319, issn 0960-894X, 7 p.Article

Structure-based design, synthesis and structure―activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding proteinEDINK, Ewald; AKDEMIR, Atilla; JANSEN, Chimed et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 3, pp 1448-1454, issn 0960-894X, 7 p.Article

Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 proteinLI, Huan-Qiu; JING YANG; SHUHUA MA et al.Bioorganic & medicinal chemistry. 2012, Vol 20, Num 14, pp 4194-4200, issn 0968-0896, 7 p.Article

Chemical genomics : a challenge for de novo drug designDEAN, P. M.Molecular biotechnology. 2007, Vol 37, Num 3, pp 237-245, issn 1073-6085, 9 p.Article

A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesisKANKANALA, J; LATHAM, A. M; JOHNSON, A. P et al.British journal of pharmacology. 2012, Vol 166, Num 2, pp 737-748, issn 0007-1188, 12 p.Article

Pyrazolopyridine inhibitors of B-Raf^V600E. Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitorsWENGLOWSKY, Steve; MORENO, David; LAIRD, Ellen R et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 19, pp 6237-6241, issn 0960-894X, 5 p.Article

The central valine concept provides an entry in a new class of non peptide inhibitors of the p53―MDM2 interactionFURET, Pascal; CHENE, Patrick; DE POVER, Alain et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 10, pp 3498-3502, issn 0960-894X, 5 p.Article

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2LABADIE, Sharada; DRAGOVICH, Peter S; HURLEY, Christopher A et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 24, pp 7627-7633, issn 0960-894X, 7 p.Article

Discovery of novel leukotriene A₄ hydrolase inhibitors based on piperidine and piperazine scaffoldsSANDANAYAKA, Vincent; MAMAT, Bjorn; BHAGAT, Nikhil et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 9, pp 2851-2854, issn 0960-894X, 4 p.Article

Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimizationDAVIES, Nicholas G. M; BROWNE, Helen; MANSELL, Howard et al.Bioorganic & medicinal chemistry. 2012, Vol 20, Num 22, pp 6770-6789, issn 0968-0896, 20 p.Article

Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitorsSCHEIPER, Bodo; MATTER, Hans; STEINHAGEN, Henning et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 18, pp 5480-5486, issn 0960-894X, 7 p.Article

Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidinesBARDELLE, Catherine; COLEMAN, Tanya; ROBINS, Peter et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 21, pp 5717-5721, issn 0960-894X, 5 p.Article

Vancomycin analogs: Seeking improved binding of D-Ala-D-Ala and D-Ala-D-Lac peptides by side-chain and backbone modificationsLEUNG, Siegfried S. F; TIRADO-RIVES, Julian; JORGENSEN, William L et al.Bioorganic & medicinal chemistry. 2009, Vol 17, Num 16, pp 5874-5886, issn 0968-0896, 13 p.Article

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitorsPOULSEN, Anders; WILLIAMS, Meredith; MYSORE NAGARAJ, Harish et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 2, pp 1009-1013, issn 0960-894X, 5 p.Article